Mechanics and performance of autoinjectors for prefilled syringes
Autoinjectors are increasingly used for self-administration of drugs via prefilled syringes. They control injection speed and pressure while concealing the needle to reduce patient anxiety. Due to their complex internal mechanics, non-destructive analytical techniques are essential to evaluate their performance and reliability.
High-resolution Synchrotron-CT of autoinjector devices
Synchrotron-CT is an analytical technique that allows to resolve with three-dimensional detail all the internal components of an autoinjectors: springs, plungers, syringe, safety mechanisms, etc.
Porosity Analysis
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Answers to the most frequently asked questions
Synchrotron-CT has been applied to typical pre-filled syringe autoinjectors from different pharmaceutical companies.
Synchrotron-CT provides a high-resolution three-dimensional representation of the sample geometry, internal structures and how they interact.
The high brilliance of Synchrotron X-rays enables three-dimensional high-resolution analysis of whole autoinjectors in only a few minutes, without need to open or damage the sample.
By understanding the behavior and interaction between internal components, pharmaceutical industry can improve the final product.
Yes, of course. We are here to advise you without obligation and to find out whether we can support you. Please do not hesitate to contact us.
Insights from customer projects
These projects show how we work with our customers to analyze complex material challenges and generate relevant insights using neutron and synchrotron techniques.
The combination of neutron imaging and synchrotron X-ray tomography provided valuable insights into the dynamics of liquid movement in staked-in-needle pre-filled syringes. The detailed morphological analysis enhanced the understanding of microstructural arrangements within the needle. This research contributes to addressing the issue of needle clogging and can guide the development of strategies to improve pre-filled syringe performance significantly.”
Dr. Guangli Hu, Principal Scientist, Device Development,
Merck & Co., Inc.Discuss your challenge with us
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